Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma

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Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma

INTRODUCTION Anti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, previous large studies of Japanese patients with scleroderma reported that anti-PM/Scl are not ...

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Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma.

OBJECTIVE Although some antiphospholipid antibodies (Abs) are found in patients with localized scleroderma (LSc), Ab against phosphatidylserine-prothrombin complex (PS/PT) has not been examined. We investigated anti-PS/PT Ab levels in patients with LSc. METHODS IgG anti-PS/PT Ab levels in serum samples taken from patients with LSc (n = 42) were measured using ELISA. RESULTS IgG anti-PS/PT A...

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Antiphospholipid Antibodies and Systemic Scleroderma

OBJECTIVE Antiphospholipid antibodies (APLs) could be associated with an increased risk of vascular pathologies in systemic scleroderma. The aim of our study was to search for APLs in patients affected by systemic scleroderma and to evaluate their involvement in the clinical manifestations of this disease. MATERIALS AND METHODS We conducted a cross-sectional descriptive study, from January 20...

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Antiphospholipid Antibodies and Systemic Scleroderma

Dear Editor: We read with great interest the article by Touré and colleagues published in a recent issue of your journal, entitled " Antiphospholipid Antibodies and Systemic Scleroderma ". In this study, they investigated 40 patients with systemic scleroderma (SSc) for the presence of antiphospholipid antibodies (aPLs). Overall, they found aPLs in 23 (57.5%) patients. The most frequently encoun...

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Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases.

OBJECTIVES Autoantibodies to the dense fine speckled 70 (DFS70) antigen are common among antinuclear antibodies (ANA) positive healthy individuals (HI). We assessed the prevalence of anti-DFS70 antibodies in patients with and without ANA-associated rheumatic diseases (AARDs) by two methods: chemiluminescent immunoassay (CIA) and an indirect immunofluorescence (IIF) assay based on immunoadsorpti...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2015

ISSN: 1478-6354

DOI: 10.1186/s13075-015-0573-x